在线订购 免费订购热线:021-59541103 021-60443211
联系人:高小姐
电话:021-59541103 021-60443211
手机:13585831301
Q Q: 3004967995
Email:3004967995@qq.com
详细地址:上海市嘉定区澄浏公路52号中科院技术转移中心24号楼
化学性质:
规格 | 10g 50g |
CAS | 834-28-6 |
别名 | N/A |
化学名 | 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine;hydrochloride |
分子式 | C10H16ClN5 |
分子量 | 241.72 |
溶解度 | ≥ 12.1mg/mL in DMSO |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
Phenformin hydrochloride is an anti-diabetic drug from the biguanide class, can activate AMPK activity.
Phenformin stimulates the phosphorylation and activation of AMPKalpha1 and AMPKalpha2 without altering LKB1 activity[1]. Phenformin increases AMPK activity and phosphorylation in the isolated heart, the increase in AMPK activity is always preceded by and correlated with increased cytosolic [AMP][2]. Phenformin is a 50-fold more potent inhibitor of mitochondrial complex I than metformin. Phenformin robustly induces apoptosis in LKB1 deficient NSCLC cell lines. Phenformin at 2 mM similarly induces AMPK signaling as shown by increased P-AMPK and P-Raptor levels. Phenformin induces higher levels of cellular stress, triggering induction of P-Ser51 eIF2α and its downstream target CHOP, and markers of apoptosis at later times. Phenformin induces a significant increase in survival and therapeutic response in KLluc mice following long-term treatment[3]. Phenformin and AICAR increases AMPK activity in H441 cells in a dose-dependent fashion, stimulating the kinase maximally at 5-10 mm and 2 mm, respectively. Phenformin significantly decreases basal ion transport (measured as short circuit current) across H441 monolayers by approximately 50% compared with that of controls. Phenformin and AICAR significantly reduce amiloride-sensitive transepithelial Na+ transport compared with controls. Phenformin and AICAR suppress amiloride-sensitive Na+ transport across H441 cells via a pathway that includes activation of AMPK and inhibition of both apical Na+ entry through ENaC and basolateral Na+ extrusion via the Na+,K+-ATPase[4]. Phenformin-treated rats reveals a tendency towards a decrease in blood insulin level (radioimmunoassay)[5].
Phenformin increases levels of P-eIF2α and its target BiP/Grp78 in normal lung as well as in lung tumors of mice[3].
特别提醒:
1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗,食品及化妆品等用途。请勿存放于普通住宅区。
2. 为了您的安全和健康,请穿好实验服并佩戴一次性手套和口罩操作。
原创作者:上海莼试生物技术有限公司
留言注意事项:
1.遵守中华人民共和国有关法律、法规,尊重网上道德,承担一切因您的行为而直接或间接引起的法律责任。
2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。
3.未经本站同意,任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。
您感兴趣的产品* | |
您的单位* | |
联系人* | |
联系电话* | |
详细地址* | |
常用邮箱* | |
请输入您对我们的意见或建议* | |
验证码* | |
产品订购说明:
1、报价含普票、运费。
2、常用试剂备货充足,除对温度要求极其严格的产品当天可发货。
3、进口原装产品要3-6周的货期,详细情况请咨询客服。
4、订货时间为工作日每周一至周五16:00之前。
5、如需代为检测,标本对环境温度高,可联系客服安排专人取样(限省内客户)。
6、代测免收代测费,一周出结果。
7、产品因运输途中包装破损请拒绝签收,做退回。我们将在24小时之内为您补发 损坏产品。
8、如因单位财务制度原因,可申请先发货,报账后付款(此条款仅限医院、学校信誉良好客户)。
普票汇款信息
账 户 名:上海生物
开 户 行:中国银行山东省分行营业部
账 号:2169 2341 6278