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化学性质:
规格 | 1mg 5mg 10mg |
CAS | 17954-98-2 |
别名 | Narthesterol |
化学名 | cholest-5-ene-3β,22R-diol |
分子式 | C27H46O2 |
分子量 | 402.7 |
溶解度 | ≤20mg/ml in ethanol;0.1mg/ml in DMSO;2mg/ml in dimethyl formamide |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice |
产品描述:
EC50: 325 nM
22(R)-hydroxy cholesterol is an endogenous agonist for liver X receptors (LXRs).
The liver X receptors, LXRR and LXRα, together with the farnesoid X receptor, FXR, form a subfamily of these orphan receptors. Recently, it has been reported that LXR and FXR are hormone receptors for oxysterols and bile acids, respectively.
In vitro: Previous study found that 22(R)-hydroxycholesterol was only found in the adrenals as an intermediate in pregnenolone biosynthesis, not similar with 24(R), 25-epoxycholesterol and 20(S)-hydroxycholesterol. In addition, the hydroxyl groups of 22(R)-hydroxycholesterol as well as its analogs of 23(S)-hydroxycholesterol and 24(S)-hydroxycholesterol would all lie between 2.0-2.5 from Trp443 [1]. In another study, the ABC1 mRNA expression could be induced in an additive fashion by 22(R)-hydroxycholesterol and 9-cis-retinoic acid in cultured macrophages, indicating induction by nuclear hormone receptors of the liver X receptor and retinoid X receptor family. Moreover, the upstream promoter was induced 7-fold by the treatment of 22(R)-hydroxycholesterol when transfected into RAW macrophages [2].
In vivo: So far, there is no animal in vivo data reported.
Clinical trial: Up to now, 22(R)-hydroxy cholesterol is still in the preclinical development stage.
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原创作者:上海莼试生物技术有限公司
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