产品目录

规格	5mg 10mg 50mg 100mg
CAS	19608-29-8
别名	17α-propionate; CB-03-01
化学名	[(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
分子式	C24H34O5
分子量	402.52
溶解度	DMF: 20mg/mL,DMSO: 10mg/mL,Ethanol: 20mg/mL,Ethanol:PBS (pH 7.2) (1:9): 0.1mg/mL
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Acne vulgaris is a disorder of the pilosebaceous unit in which the androgens contribute to its onset and persistence. Though the use of antiandrogens is potentially effective; topical use of antiandrogens are not available on the market. Cortexolone 17a-propionate (CB-03-01) is a new potent topical antiandrogen potentially useful in acne vulgaris. CB-03-01 is a new chemical entity that acts at the level of the skin androgen receptor, which blocks testosterone and di-hydrotestosterone from binding to the receptor in the cell.

In vitro: The aim of one in vitro study was to investigate the antiandrogenic activity of a new monoester of cortexolone, cortexolone 17alpha-propionate. Although the compound displayed a strong local antiandrogenic activity in hamster's flank organ test. Its pharmacological activity seemed to be primarily related to its ability to antagonistically compete at androgen receptor level; nevertheless its primary pharmacological target needs to be further investigated. The topical activity of cortexolone 17alpha-propionate with the apparent absence of systemic effects makes this compound to have the potential of representing a novel and safe therapeutic approach for androgen-dependent skin disorders. [1].

In vivo: Cortexolone 17alpha-propionate displayed a strong local antiandrogenic activity in hamster's flank organ test, however, it did not exhibit antiandrogenic activity in rats, nor did it affect gonadotropins hypersecretion. As topical antiandrogen, the steroid resulted about 4 times more active than progesterone and, when compared to known antiandrogen standards, it was about 3 times more potent than flutamide, about 2 times more effective than finasteride and approximately as active as cyproterone acetate. Its pharmacological activity seemed to be primarily related to its ability to antagonistically compete at androgen receptor level; nevertheless its primary pharmacological target needs to be further investigated [1].

Clinical trial: In 2011, Trifu et al. evaluated the safety and efficacy of cortexolone 17alpha-propionate 1% cream in acne vulgaris in comparison to placebo and to tretinoin 0.05% cream. A total of 77 male subjects were randomized to receive cortexolone 17alpha-propionate 1% cream, tretinoin 0.05% cream or placebo once nightly for 8 weeks. cortexolone 17alpha-propionate 1% cream was statistically better than placebo in reducing total lesion count, inflammatory lesion count and Acne Severity Index, without any major side effects. Further, cortexolone 17alpha-propionate 1% cream showed a faster onset of all the abovementioned improvements and was clinically more effective than tretinoin 0.05% cream, although the results were not statistically significant [2]

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

原创作者：上海莼试生物技术有限公司

在线咨询

留言注意事项：

1.遵守中华人民共和国有关法律、法规，尊重网上道德，承担一切因您的行为而直接或间接引起的法律责任。

2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。

3.未经本站同意，任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。

您感兴趣的产品*
您的单位*
联系人*
联系电话*
详细地址*
常用邮箱*
请输入您对我们的意见或建议*
验证码*

订货流程

产品订购说明:

1、报价含普票、运费。

2、常用试剂备货充足，除对温度要求极其严格的产品当天可发货。

3、进口原装产品要3-6周的货期，详细情况请咨询客服。

4、订货时间为工作日每周一至周五16:00之前。

5、如需代为检测，标本对环境温度高，可联系客服安排专人取样（限省内客户）。

6、代测免收代测费，一周出结果。

7、产品因运输途中包装破损请拒绝签收，做退回。我们将在24小时之内为您补发损坏产品。

8、如因单位财务制度原因，可申请先发货，报账后付款（此条款仅限医院、学校信誉良好客户）。

付款方式

普票汇款信息

账户名：上海生物

开户行：中国银行山东省分行营业部

账号：2169 2341 6278

为方便广大客户办理货款我公司提供多个银行的账户，学校、医院客户购买产品如因单位财务制度原因可先发货待报账后汇款，请及时告知销售人员已做具体操作。

17 alpha-propionate

产品目录

联系我们

技术服务

商品详情购物流程代测服务付款方式常见问题

在线咨询

同类产品

订货流程

付款方式