产品目录

规格	10mM (in 1mL DMSO) 100mg
CAS	446-72-0
别名
化学名	5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
分子式	C15H10O5
分子量	270.24
溶解度	≥ 55.6mg/mL in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

产品描述：

Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

Genistein inhibits serum-stimulated growth of MCF-7 and T47D ER+ cells with IC50 values of 7.6 and 8.7 μg/mL by dye exclusion, respectively, and 8.7 and 10.6 μg/mL by [3H]thymidmne incorporation, respectively. These values are similar to the IC50 values of 9.4 and 7 μg/mL for MCF-7 and T47D ER+ cells, respectively, obtained with the MTT assay. Additionally, Genistein at concentrations up to 20 μg/mL does not alter MTT mitochondrial reduction when compared to control cells in an 8 h incubation period. Furthermore, neither biochanin A or daidzein are found to interfere with the MTT assay at IC50 concentrations. Therefore, the MTT assay is valid for determining growth inhibition by Genistein at concentrations under 20 μg/mL in the systems studied[1].

In the present study, the effective dose of morphine caused a significant decrease in testis weight of mice compared to Saline group (p=0.00). Moreover, testis weight are significantly increase in treated animals with Genistein and Genistein plus morphine in all doses in comparison with morphine group (p=0.028). Morphine caused a significant decrease in the testosterone, LH and FSH hormones compared to saline group (p=0.00). In addition, the testosterone, LH and FSH hormones increased significantly in Genistein (p0.05; P>0.05). Significant decreasing of the protein expression of PPARγ in liver is observed when Genistein is added to rats, compared to either HFD group or HFD-BPA group[3].

特别提醒：

1. 本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。

2. 为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。

原创作者：上海莼试生物技术有限公司

在线咨询

留言注意事项：

1.遵守中华人民共和国有关法律、法规，尊重网上道德，承担一切因您的行为而直接或间接引起的法律责任。

2.请您真实的反映产品的情况,不要捏造、诬蔑、造谣。如对产品有任何疑问,也可以留言咨询。

3.未经本站同意，任何人不得利用本留言簿发布个人或团体的具有广告性质的信息或类似言论。

您感兴趣的产品*
您的单位*
联系人*
联系电话*
详细地址*
常用邮箱*
请输入您对我们的意见或建议*
验证码*

订货流程

产品订购说明:

1、报价含普票、运费。

2、常用试剂备货充足，除对温度要求极其严格的产品当天可发货。

3、进口原装产品要3-6周的货期，详细情况请咨询客服。

4、订货时间为工作日每周一至周五16:00之前。

5、如需代为检测，标本对环境温度高，可联系客服安排专人取样（限省内客户）。

6、代测免收代测费，一周出结果。

7、产品因运输途中包装破损请拒绝签收，做退回。我们将在24小时之内为您补发损坏产品。

8、如因单位财务制度原因，可申请先发货，报账后付款（此条款仅限医院、学校信誉良好客户）。

付款方式

普票汇款信息

账户名：上海生物

开户行：中国银行山东省分行营业部

账号：2169 2341 6278

为方便广大客户办理货款我公司提供多个银行的账户，学校、医院客户购买产品如因单位财务制度原因可先发货待报账后汇款，请及时告知销售人员已做具体操作。

Genistein

产品目录

联系我们

技术服务

商品详情购物流程代测服务付款方式常见问题

在线咨询

同类产品

订货流程

付款方式